Revive Therapeutics (RVV.V) is a specialty life sciences company focused on the research and development of therapeutics for medical needs and rare disorders. The company offers cannabinoid pharmaceutical portfolio that focuses on rare inflammatory diseases. It is developing Bucillamine, which is in Phase 3 clinical study for the treatment of infectious diseases, including influenza and COVID-19.
Today, the Company provided an update on the development of a next generation lyophilized formulation of Bucillamine. The Company expects to have its novel lyophilized formulation of Bucillamine ready for production with a contract development manufacturing organization for clinical evaluation in 2024.
At the heart of Revive’s portfolio is Bucillamine, a drug with potential applications in multiple therapeutic areas. Notably, the company has initiated the development of a next-generation formulation of Bucillamine, exploring its potential in new treatment paradigms. This initiative builds on the company’s earlier efforts, where Bucillamine was studied in a Phase 3 clinical trial for the treatment of COVID-19.
Under an agreement with the University of Waterloo, formulation development work is ongoing and is expected to be completed by the end of the year. The research team has improved the solubility of Bucillamine and subsequent lyophilization has resulted in more than double enhancement of solubility, which would unlock the therapeutic utility of Bucillamine for public health medical emergencies, including pandemic influenza, emerging infectious diseases, and medical countermeasure incidents and attacks.
The novel Bucillamine formulation could support the continuation of the research project the Company has with the Defence R&D Canada – Suffield, an agency of the Canadian Department of National Defence, to evaluate Bucillamine as a potential treatment for nerve agent exposure.
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